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While treatment length varies significantly from person to person, with some using semaglutide for shorter periods and others for longer durations under clinical supervision (which may range from several months to longer-term use), the way it leaves your system follows a similar general pattern

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Phase 2 trials reported mean systolic blood pressure reductions of approximately 46 mmHg in higher-dose groups, alongside a modest increase in heart rate consistent with the GLP-1 drug class

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