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[DOI] [PubMed] [Google Scholar] 39.Hernandez A.F., Green J.B., Janmohamed S., et al

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Enteral Routes (Via Gastrointestinal Tract) Oral (PO) Most common and convenient route Drug absorbed mainly in the small intestine Subject to first-pass metabolism (liver) Clinical Insight: Suitable for chronic therapy but not ideal in vomiting/unconscious patients Sublingual / Buccal Absorption through oral mucosa Bypasses first-pass metabolism Rapid onset Example: Nitroglycerin in angina Rectal Used when oral route is not feasible Partial avoidance of first-pass metabolism Limitation: Erratic absorption 2

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The pipette solution for whole-cell recordings was modified to include an intracellular dye (Alexa Fluor 350 hydrazide dye) and contained: 120 mM K-gluconate, 10 mM KCl, 10 mM HEPES, 5 mM EGTA, 1 mM CaCl 2 , 1 mM MgCl 2 and 2 mM MgATP, and 0.03 mM Alexa Fluor 350 hydrazide dye (pH 7.3)