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At the ingredient level, this is a documented mechanism - the compound acts on the microbial composition rather than delivering butyrate directly

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For GI-specific applications, BPC-157 has been studied in two human trials for ulcerative colitis and multiple sclerosis, with no reported toxicity and an LD1 (lethal dose) that was never achieved in preclinical models

In terms of overall safety and effectiveness for weight loss, its hard to compare berberine to prescription weight loss medications

Give each dose level at least 3 to 4 weeks before making a decision about tolerability