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This includes prioritizing drugs with proven outcome benefits in those at high risk, even as metformin remains appropriate for many others

The best option depends on your symptoms, medical history, and treatment goals, which is why peptide therapy should be tailored and medically supervised rather than chosen as a one-size-fits-all solution

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However, Pioglitazone and Saxagliptin are not recommended as Glucose-lowering agents since they are linked to an increased HF hospitalization risk [49, 98, 99]