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73 Target lipid homeostasis and fibrogenesis Allosteric inhibitors of acetyl-coenzyme A carboxylases (ACC) ACC1 and ACC2 were suggested to inhibit hepatic de novo lipogenesis and improve steatosis, inflammation, and fibrosis

Binding to this allosteric site can still influence the sensitivity and activity of the receptor, but could lead to drugs with fewer off-target side-effects, since GLP-1 is involved in many different metabolic signalling pathways

This metabolic penalty persists for years and makes maintaining weight loss without pharmacological support extraordinarily difficult

Whether youre taking a GLP-1 or not, its wise to monitor your scale weight while on a weight loss routine

Funding This paper was supported by the National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre