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Notably, this heat stroke-induced LIRI differs fundamentally from reperfusion injury in hypovolemic shock or surgical contexts: in heat stroke, reperfusion is preceded by hyperthermia-induced endothelial damage and systemic inflammatory priming, which amplify oxidative stress (e.g., xanthine oxidase activation) and neutrophil infiltration
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As expected, the hydrodynamic size of NPs, determined by the DLS technique, is significantly higher in comparison with the one obtained by TEM or AFM
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