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This evidence is backed up by a study conducted by Hasegawa et al., which found that GLP-1 administration improves dyslipidemia by inhibiting HMG-CoA reductase in T2DM patients [65]

372 All these astrocytic changes result in considerable and often irreversible neuronal damage, with about 50% of patients demonstrating persistent neurological manifestations even after liver replacement and normalisation of blood ammonium

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As a result, expanding access to these therapies could have both clinical and economic advantages