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Methods Materials Tetrahydrofuran (THF), toluene and ethanol were distilled from sodium benzophenone ketyl, calcium hydride and magnesium, respectively, under nitrogen immediately prior to use

And its important

The volume of diluent used determines the final concentration, which in turn affects stability and dosing convenience

222,224 In addition, it has been shown that NAPRT gene promoter can be hypermethylated resulting in the inhibition of NAPRT epigenetic expression in some types of tumors