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This helps seal in moisture and prevents transepidermal water loss (TEWL)

They soon realised that overproduction of ketones in the body was responsible for the coma, now known as diabetic ketoacidosis (VanItallie, Nufert)

A randomized trial assessing the effect of tirzepatide (Mounjaro/Zepbound) found that withdrawing tirzepatide led to substantial regain of lost weight in less than two years

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Gordon KB, Langley RG, Gottlieb AB, et al