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If LDL-C is at target (generally below 70 mg/dL for high-risk ASCVD patients per ACC/AHA 2019 guidelines), there is no phenotypic signal of interference

HUBERMAN: So unlike your brain cells that for instance, after about age 25, you're not adding or deleting many brain cells, at least provided there's no injury or nerve degenerative disease

L.WeinansH.et al (2015)

The cardioprotective mechanism proposed involves the enhancement of mitochondrial function, the reduction of oxidative stress, the attenuation of inflammation, and the inhibition of apoptosis (Luna-Marco et al., 2023

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log-rank test, P = 0.0071) and a hazard ratio of 5FU with metformin to 5FU alone of 0.3330