glp-1 aspiration 🇬🇧 Perioperative Management of New Popular Agents: Agonists (GLP-1 RA: semaglutide, tirzepatide) These drugs delay gastric emptying → patients may have a “full stomach” despite fasting This increases risk of regurgitation 👉GLP1 medications delay gastric emptying.

Nutrition considerations with anti-obesity medications

After stopping, it takes roughly 5 half-lives (about 30 days) for the compound to clear

GLP-1 reduces endoplasmic reticulum stress and apoptosis induced by hyperglycaemia and regulates mitochondrial function via stimulation of optic atrophy protein 1 [69]

Peptide drugs are highly specific, with less toxicity and fewer drug interactions

Ideal candidates understand realistic before-and-after outcomes and commit to following all pre- and post-operative care instructions

While the long half-life of semaglutide theoretically supports less frequent dosing, clinical data supports either daily oral or weekly injectable schedules