Your body produces additional stomach acid and digestive enzymes while waiting, which can ferment undigested carbohydrates and generate extra gas that must be released as burps
doi: 10.3390/ijms20071584 57 NeurathMFArtisDBeckerC
Microdosing may not produce enough benefit to justify the cost and commitment
For example, high-fat feeding alters the small intestinal microbiota to increase intestinal, brain, and circulatory levels of taurine-conjugated bile acids, including and taurochenodeoxycholic acid (TCDCA), which is an FXR agonist 272
Whilst this might seem beneficial for patients with obesity, excessive or rapid weight loss can lead to nutritional deficiencies, muscle wasting, and metabolic complications
The mechanism by which metformin causes GI side effects remains uncertain