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Clinical & Experimental Metastasis, 27(2), 83-90

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Specifically, the variants G247Vfs*6 and G283R exhibit embryonic lethality upon exposure to -BB at mM concentrations, closely mimicking the response observed in the knockout alleles

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We observed that Nlrp3 / macrophages present an intrinsically protective redox state and this could be the reason why macrophages did not produce ROS after sUA+LPS stimulus