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Although often presented as a broadly beneficial polyphenol, resveratrol has also been repeatedly flagged as a potentially PAINS-susceptible molecule, owing to its redox activity, metal-chelating properties, and tendency to interfere with multiple assay formats in a non-specific manner as highlighted in the Nature commentary ( Weight of evidence: Overall evidence is Low : an add-on signal on hyperactivity without core-symptom change

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AOD-9604 : Additional support with body composition, particularly when a non-GLP-1 approach is preferred as part of a broader metabolic strategy

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Additionally, differences in detection methodologies and study designs should not be overlooked