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The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM- V) defines ASD as having "deficits in social interaction and communication together with restricted and repetitive behaviors and interests" (American Psychiatric Association, 2013)

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While scientific and policy responses have traditionally focused on isolated strategies, there is an increasing need to adopt a holistic model that integrates knowledge from physiology, endocrinology, nutrition, immunology, genetics, epigenetics, and microbiome research, alongside socio-economic and environmental factors [141]

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