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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

Packaging container: Amber Glass Made Multi-Dose Vial-Picture Courtesy: Vet-N-Pet DIRECT Multi-dose vials are used to dispense vitamin b12 injection for dogs and these vials contain preservatives to avoid instability in formulation

PLoS One 2014

[2] Nitrous oxide overdose or overuse converts the active monovalent form of vitamin B 12 to the inactive bivalent form

doi:10.1146/annurev.nutr.24.012003.132440