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This effect is believed to occur through PYY(136) binding to Y1 receptors in the hypothalamus, which activates NPY/AgRP neurons, increases NPY expression in the ARC, and indirectly inhibits pro-opiomelanocortin/Cocaine amphetamine regulated transcript (POMC/CART) neurons [47, 49]

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Data availability Raw sequencing data for fetal and adult epithelial analyses are available at Array Express ( under accession numbers E-MTAB-10187, E-MTAB-8901, E-MTAB-9363, E-MTAB-9489, E-MTAB-9536, and E-MTAB-9543, as well as at GEO under accession numbers GSE158702, GSE158703, GSE158704, GSE158705, GSE158706, GSE158707, GSE158708, GSE158709, GSE158710, GSE158711, GSE158712, GSE158713, GSE158714, and GSE185224

Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion