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Metformin primarily reduces hepatic glucose production and improves peripheral insulin sensitivity, while tirzepatide enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety

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Several studies have demonstrated that in vitro heat stress has detrimental effects on various aspects of cytoplasmic and nuclear oocyte maturation 70 , including cytoskeletal rearrangement 14 , meiotic spindle formation 14,67 and early embryonic mitotic failure 71

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