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Multiple studies demonstrate that proliferation due to incretin mimetics can lead to duct occlusion, promoting the premature release of pancreatic enzymes, thereby triggering acinar cell death 18,26

Reducing the dose of insulin secretagogue or insulin may be necessary

Approximately 85% of total cellular glutathione is free and unbound whilst the rest is bound to proteins [30]

A clear supernatant (50 l) with added 50 l mobile phase (reconstitution solution) from each extraction was then transferred into a 250 l autosampler vial