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TSA/TSW increases the difficulty in symptom management, including erythroderma, sleep disturbance, and recurrent Staphylococcus infections [18]

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Acknowledgements This work was supported in part by the grants from the United States National Institute of Health NIDDK including T32DK07751 (JLC), the Diabetes Research and Training Center grant P60DK079637 (JSF), and DK057501 and DK08098 (XC)

Nasal delivery avoids injection site risks (infection, bruising, irritation) but introduces nasal mucosal irritation and formulation stability concerns