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Typical titration schedule in trials: Start at 2 mg weekly Increase every 4 weeks: 2 mg 4 mg 6 mg 9 mg or 12 mg (depending on target dose) This means it takes 3-4 months to reach the maximum dose Meaningful weight loss becomes apparent after reaching therapeutic doses and maintaining them for several weeks

Based on current clinical evidence, Mounjaro (tirzepatide) is generally the best tolerated of the available options, with lower rates of nausea compared to semaglutide at equivalent weight loss doses

No weight loss goal justifies potential fetal harm

Your healthcare provider will help determine the appropriate treatment length based on your specific situation and progress.

If you are tolerating your current dose and seeing results, there is no requirement to escalate

Harris, Triple-Hormone Combination Retatrutide Induces 24% Body Weight Loss, JAMA, vol