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Before starting semaglutide, inform your doctor if you have any pancreatic or stomach problems, severe dehydration, or diabetic ketoacidosis, and consult your doctor if you are pregnant or breastfeeding

Metformin is a biguanide that lowers hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity

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48 , 49 , 50 This causes disrupted vascular function and hypertension