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doi: 10.1002/anie.201000044 4 SwallahMSSunHAffohRFuHYuH

Recent evidence suggests that this temporal regulation involves not only the hypothalamicpituitaryadrenal axis but also mesolimbic reward pathways, where circadian fluctuations in monoaminergic neurotransmission (particularly dopamine and serotonin) influence endocrine responses to environmental cues (116, 117)

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It is included on the 2026 WADA Monitoring Program, which tracks markers of semaglutide and tirzepatide use across sports without imposing sanctions, allowing WADA to identify patterns of potential misuse that may inform future Prohibited List decisions

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