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General overview of HSP70s Members The term HSP70 refers to a family of chaperones with a molecular weight of approximately 70 kDa, consisting of 13 members in humans with distinct functions and intracellular localizations (Kampinga et al., 2009), derived from corresponding genes, whereas HSPA7 is usually considered as a pseudogene (Li et al., 2022)

Collectively, these studies strongly implicate a role for glucosylated ceramides in increased adipose tissue inflammation, peripheral insulin resistance, and hepatic steatosis

Additionally, H 2 O 2 diffuses across the cell membrane via aquaporin aqueous channels (AQPs), transposing redox signals from the location where the redox signal is generated to the site of interest [9]

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