This narrative review aims to provide a synthesis of current knowledge regarding the anti-inflammatory properties of GLP-1, with a particular focus on safety concerns and potential future directions for its use in IBD management
In the absence of structural information for the GLP-1R, the design of acid-containing ligands was driven by SAR and the observation that polarity was better tolerated in the benzimidazole (red) region (Fig
nausea, vomiting, diarrhoea, and constipation) are common [3, 5], serious adverse effects (e.g
Endosomal escape is crucial for the release of therapeutic agents into the cytoplasm, where they can exert their intended effects (Fig
Even if a patients final height remains below average, it is possible that a gain in adult height could affect the daily lives of patients with SPIGFD
M., Benayoun, B