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Zhuohan Hu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The past years have seen significant progress in the development of GLS inhibitor, BPTES, as a promising drug candidate by researchers

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Meanwhile, NNMTi treatment significantly increased energy expenditure in mice, an effect closely related to elevated NAD levels following NNMT inhibition

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