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Tyr is synthesized via two alternative routes mediated by a TyrA family enzyme, prephenate, or arogenate dehydrogenase (PDH/TyrA p or ADH/TyrA a ), typically found in microbes and plants, respectively

doi: 10.1006/bcmd.2000.0288

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When combined with donepezil, the BDNF increase was even more pronounced and sustained through the end of the study period