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In addition, various other nanoparticles have also been shown to improve the immunosuppressive tumor microenvironment by reducing MDSCs infiltration or decreasing MDSCs activity, such as high-density lipoprotein-like nanoparticles (HDL-NP) can specifically target the high-affinity receptor B-1 scavenger receptor (SCARB1) of spherical high-density lipoprotein (HDL) expressed by MDSCs thereby inhibiting MDSCs activity and enhancing the immune response to cancer and significantly inhibiting tumor growth (131)

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