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In fact, NADH is an inhibitor of the TCA enzyme isocitrate dehydrogenase 93 , a protective mechanism to prevent overloading of the ETC and excessive ROS generation

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This immunometabolic reprogramming is governed by signaling pathways (mTOR, AMPK, HIF-1) that respond to acute environmental cues rather than genetic transformation, and rapidly reverts to oxidative phosphorylation upon stimulus withdrawal (56, 57)

Association of acetaminophen use during pregnancy with behavioral problems in childhood: evidence against confounding