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4 Classification of melasma Melasma can be clinically classified as centrofacial (with the highest incidence rate), malar and mandibular skin patches
It also acts as a physical and metabolic (2) barrier that regulates the transport of substances in a bi-directional way (3) and protects the central nervous system (CNS) from unwanted compounds playing a crucial role in maintaining its homeostasis (2, 3)
Adverse events are usually limited to injection-site reactions: transient soreness, redness, occasional bruising
628 However, caregivers of individuals with a formal dementia diagnosis were also more engaged in communication during doctors visits and more likely to receive caregiver training than those who assisted someone without a diagnosis of dementia, suggesting the importance of linking support to dementia diagnostic procedures
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