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It is most effective when

PubMed CrossRef McIntyre RS

This practice has actually been going on for many centuries

If you miss a dose by fewer than 4 days, take it as soon as you remember and resume your normal weekly schedule

Therefore, the problem that the agents successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events (60), may be at least partly solved with the more suited cuprizone model that reflects a toxic experimental model (12)