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J Toxicol Pathol 14, 15155

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While medication alone wont solve this global health crisis, GLP-1 therapies can help millions overcome obesity and reduce its associated harms. The WHO did qualify its recommendations, saying endorsement is conditional due to limited data on their long-term efficacy and safety, maintenance and discontinuation, their current costs, inadequate health-system preparedness, and potential equity implications. The drugs should not be used by pregnant women, and should be paired with evidence-based interventions like healthy diets and physical activity, the guidelines also stress

Bruls YM, de Ligt M, Lindeboom L, Phielix E, Havekes B, Schaart G, et al

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Adrenergic regulation of astroglial aerobic glycolysis and lipid metabolism: towards a noradrenergic hypothesis of neurodegeneration