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Additional adverse effects include risk of thyroid C-cell cancer, pancreatitis, severe gastrointestinal reactions, kidney injury, low blood sugar, allergic reactions, diabetic retinopathy complications, acute gallbladder disease, and increased risk for aspiration with general anesthesia

The Washington Post put it well in March 2026: "The miracle of rapid weight loss has always come with fine print." Until recently, that fine print was mostly a list of digestive complaints

Tirzepatide showed a noninferior reduction in all-cause mortality (HR 0.88, 95% CI 0.68 to 1.16), myocardial infarction (HR 0.91, 95% CI 0.73 to 1.12) and stroke (HR 0.78, 95% CI 0.59 to 1.03) compared to dulaglutide, although CIs remained compatible with no difference

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10.3389/fcell.2022.824851 Front Cell Dev Biol

Excess fat deposits in the neck and tongue increase this collapsibility