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A research article on the effectiveness and safety of the non-peptide glucagon-like peptide- 1 (GLP- 1) receptor agonist Orforlipron than once daily oral therapy for weight reduction in adults with obesity

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doi: 10.1371/journal.pmed.0020124 299

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The elevation of intracellular calcium levels and potential PKC activation may result in the exocytosis of growth hormone-containing vesicles from pituitary cells

Peptides are generally not considered safe during pregnancy and most clinicians advise stopping them well before conception