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Targeting the incretin system in obesity and type 2 diabetes mellitus

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Areas Requiring Further Investigation Further research is needed to clarify long-range receptor signaling behavior, tissue-specific pathway effects, molecular signaling durability, model-to-human translation, and how findings vary across study designs

Doctors note less common side effects that can be more serious, including pancreatitis and gallbladder problems

Because GLP-1 medications slow gastric emptying, the timing and intensity of alcohols effects may become less predictable

10.1038/nrdp.2017.38 48 KoonsG