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The high-dose long-term safety case carries materially more uncertainty than tirzepatide or semaglutide do at comparable durations

Overall, accumulating evidence suggests that paternal diabetes can program offspring metabolic outcomes through stable, heritable epigenetic modifications

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Therefore, we conclude that 5FU promotes metabolic reprogramming in drug-tolerant cells, increasing mitochondrial activity supported by an acute increase in metabolic gene transcription

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