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Variability-accommodating pharmacodynamics (time-integrated effects): When pharmacodynamic effects integrate over time and depend on the area under the curve (AUC) or sustained receptor occupancy rather than peak concentration, transient fluctuations in plasma concentration have limited clinical consequences
Injections that rely on prescription medications are sometimes the exception to this rule, but patients who fail to modify their diet and exercise regimen tend to quickly regain weight when they stop receiving the injections
For many patients, this represents a meaningful opportunity to improve metabolic health rather than just manage symptoms
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Kanavakis, E
Jan 21, 2026 12 min read IN THIS ARTICLE KEY TAKEAWAYS Weight loss includes both fat mass and lean muscle mass unless muscle is actively preserved
