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The interaction is pharmacodynamic, not pharmacokinetic

Extracellular Matrix Studies The extracellular matrix is far more than a structural scaffold: it actively influences cell behavior, signaling, and tissue organization

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Jones LA, Sinnott LT, Mutti DO, Mitchell GL, Moeschberger ML, Zadnik K

The transdermal patches or gel are easy to use, although requiring a daily administration, are generally well accepted by the patients and allow mimicking the physiological circadian rhythm of testosterone