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P-27 Genetic segregation study in patients with hereditary angio-edema due to mutation in coagulation factor XII in a population of Southern Spain Teresa De Aramburu Mera, Krasimira Baynova, Jos Ral Garca Lozano, Jose Manuel Lucena Soto, Stefan Cimbollek Spanish National Center for Angioedema Allergy Department Virgen del Roco University Hospital, Seville, Spain Allergy, Asthma & Clinical Immunology 2025, 21(Suppl 2) :P-27 Introduction: Patients with hereditary angioedema due to pathogenic variants in the coagulation factor XII gene show clinical differences not only with other forms of hereditary angioedema, but also show differences between different families with HAE-FXII and even between members of the same family