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Apigenin-7-glucoside-loaded nanoparticle alleviates intestinal ischemia-reperfusion by ATF3/SLC7A11-mediated ferroptosis

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Simultaneously, it downregulates genes associated with inflammation (IL-6, TNF-alpha), oxidative damage, fibrosis (TGF-beta in some contexts), and tissue destruction (certain metalloproteinases)

Thus, clinical trials are currently testing the following drugs in combination with CB-839: nivolumab as a treatment for melanoma, renal cell carcinoma (RCC), and NSCLC (clinicaltrials.gov ID: NCT02771626)

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