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Studies examining long-term L-citrulline use have demonstrated that supplementation may reduce systolic blood pressure and can reduce diastolic blood pressure at doses greater than or equal to six grams per day.8 Acute use of similar doses has also resulted in positive effects.9 For those at risk of heart disease and hypertension, supplementing citrulline may help prevent the need for medications down the line, though this is a sensitive enough area of your health that you should definitely speak with your doctor before taking it

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the (R)-4-chloro-3-hydroxy butyric acid alkyl ester is reacted with trimethylamine and then the reaction product is treated with hydrochloric acid to thereby prepare L-carnitine hydrochloride which is then reacted with acetic acid containing acetyl chloride to prepare acetyl L-carnitine hydrochloride