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This results in secondary effects, including leukocyte in-filtration, impaired transcellular transport, pericyte damage, expansion of the peri-vascular space, and astrocyte proliferation (30, 31)

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Some also argued that clinicians and pharmacists should be able to weigh uncertainty for an individual patient when conventional options are inadequate

If you plan to discontinue tirzepatide, consider a gradual dose reduction over 8-12 weeks