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Maha AbuZarifa, Rejean Sawh, Dr Subhash Reddy N, Muhammad Bin Salman, Yara Ashour, A special thank you to Hazem Ayash for his invaluable supervision, continuous guidance, and unwavering support throughout this project

Safe Treatment Protocols Careful monitoring at every step

486 Intellectual disability Intellectual disability (ID) is a heterogeneous genetic disorder in children with an incidence of 13%, representing a substantial public health burden

Final purified proteins were stored in 20 mM Tris-HCl pH 8.0, 150 mM NaCl buffer, unless specified otherwise, and stored at 80 C until further use

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But not every patient responds the same way