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The safety profile of SMG compared to other pharmacological therapies is important, as many other therapies have an adverse effect profile that contributes to its poor adherence [161,184]

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A peer-reviewed Phase 2 result outranks an unpublished topline press figure for reliability

Extended escalation for sensitive individuals If standard 4-week intervals produce intolerable side effects, extending each phase to 6 or 8 weeks is a reasonable modification

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