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Contrariwise, addiction is a syndrome characterized by the loss of control over the use of drugs and by compulsive and continuous use

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Sensory and sleep symptoms can be surprisingly disruptive

In clinical practice, common signs and symptoms of opioid withdrawal syndrome are hypertension, tachycardia, nausea, vomiting, diarrhea, mydriasis, piloerection, lacrimation, rhinorrhea, and insomnia (50, 51)

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