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Cardiovascular and metabolic comorbidities in patients with thyroid nodules: the impact of incidental diagnosis

doi: 10.1210/clinem/dgac163 372 YangZHuangRWangYGuanQLiDWuYet al

Malonyl-CoA:acyl-carrier protein acyltransferase (MCAT) transfers the malonyl group to the acyl-carrier-protein (ACP) [29], followed by a series of enzymatic reactions: condensation to 3-ketoacyl-ACP by 3-oxoacyl-acyl-carrier-protein synthase (OXSM) [30], reduction to 3-hydroxyacyl-ACP by 3-oxoacyl-acyl-carrier-protein reductase [31], dehydration of 3-hydroxyacyl-ACP by 3-hydroxyacyl-thioester dehydratase to 2-trans-enoyl-ACP [32,33], and a final reduction by trans-2-enoyl-CoA reductase which catalyzes the reduction of 2-transenoyl-ACP to acyl-ACP [34]

At the same time, tissue inhibitors of metalloproteinases (TIMPs) increase across all tested concentrations

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