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As Clinical Pharmacokinetics describes, semaglutide's terminal half-life of approximately 1 week comes from a fatty-acid moiety attached to the lysine in position 26, which binds the molecule to albumin and slows clearance

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PMID: 11 SatoTHayashiHHiratsukaMHirasawaN

Other methods Electroretinography and optical coherence tomography were carried out as described [58]