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[,] In drug-naive individuals with T2DM who overweight or obese, expert panel recommends initiating oral semaglutide, as the treatment offers dual benefits, achieving both significant reductions in HbA1c levels and weight loss, which are critical for managing diabetes effectively

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found that epidermis-specific Mll4 -knockout mice developed red, scaly skin (Egolf et al., 2021)

PET studies not only provide visual corroboration for this conceptual framework but also highlight the heterogeneity within patient populations, indicating that future therapeutic strategies should prioritize precise stratification to target distinct subtypes ( Figure 4 )

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