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50 & Target Kd: 65 pM (HGF) [1] In Vitro Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering

To overcome these limitations, the researchers designed and synthesized novel small molecules with improved metabolic stability, BBB penetrability, and oral activity

The products we offer are not intended to diagnose, treat, cure, or prevent any disease

In summary, the results demonstrate that Dihexa is a metabolically stable and BBB-permeable AngIV analog that effectively reverses scopolamine-induced cognitive deficits and improves spatial learning in aged rats