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If nausea occurs, split the dose into smaller amounts taken throughout the day, or switch to a sustained-release NAC formulation

Women of childbearing potential should be counseled on avoiding pregnancy while on MB therapy, and if a pregnant patient has a medical emergency like methemoglobinemia, the physician must weigh the maternal benefit against the fetal risk very carefully

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Substrate titration and time-course experiments showed that 12 h of labeling with 250500 M BP or BMP substrate provides an optimal signal-to-noise ratio (Supplementary Fig